Fluoroquinolone-Induced Fixed Drug Eruption: A Clinically Significant Case Report Case report

Abstract

Fixed drug eruption (FDE) is a well-recognized cutaneous adverse drug reaction (ADR) characterized by the recurrence of lesions at the same anatomical site upon re-exposure to the offending drug. Although most cases are benign, severe or generalized variants can significantly impair quality of life. We present the case of an 18-year-old male who developed multiple hyperpigmented patches and blistering after administration of ofloxacin, a commonly prescribed fluoroquinolone antibiotic. Lesions recurred after inadvertent re-challenge, confirming the diagnosis of drug-induced FDE. Causality assessment using both the WHO-UMC system and the Naranjo algorithm classified the event as “probable.” The patient responded well to systemic corticosteroids, topical corticosteroids, and non-sedating antihistamines, with complete resolution over three weeks. This case emphasizes the importance of careful drug history, patient counselling, and the role of pharmacovigilance in preventing recurrent ADRs.